Oct 01, 18 · A characterization of solid lipid nanoparticles (SLN) produced starting from an emulsion prepared in acidic or neutral medium and based on Gelucire ® 50/13 as lipid phase was performed by XRay Photoelectron Spectroscopy Analysis (XPS) The smallest particle size and the highest peptide content were observed for GSHSLN produced in acidic medium GSHSLN(HAc)Gelucire® 50/13, Gattefosse) may serve as both solidifying and emulsifying agents for triglycerides The excipient is primarily a mixture of PEG 1500 mono and diesters with palmitic (C 16) and stearic (C 18) acid with an HLB value of ~13 (13) It was used for the development of solid dispersion hydrophobicJun 30, 19 · Gelucire® 50/13;
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Gelucire 50/13 gattefosse-An oral pharmaceutical composition of isotretinoin containing at least two lipidic excipients, one of them being hydrophilic (ie having an HLB value superiorJun 18, 18 · The final product is either a pure PEG ester (Gelucire® 48/16) or a mixture of PEG esters and mono, di and triglycerides (Gelucire® 44/14 and Gelucire® 50/13) The fatty acid repartition depends on the original raw material Gelucire® 48/16 and Gelucire® 50/13 are composed mainly of stearic and palmitic acids, whereas lauric acid is the
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Jan 01, 17 · The lipid components Gelucire® 50/13 (stearoyl macrogolglycerides, GATTEFOSSÉ GmbH, Bad Krozingen, Germany), Witepsol® S55 (solid triglycerides containing hydrogenated cocoglycerides, beeswax and ceteareth25, CREMER OLEO GmbH & Co KG, Hamburg, Germany), and Capryol® 90 (propylene glycol monocaprylate, Gattefossé GmbH, Bad KrozingenGelucire 44/14 Acylglycerol fraction PEG ester fraction Figure 1 Thermograms of the first melting of Gelucire® 44/14 (solid line), the acylglycerol fraction of Gelucire® 44/14 (dotted line), and the PEG ester fraction of Gelucire® 44/14 (dashed dot dot line) at a heating rate of 3 °C/min 268 OCL VOL 16 N° 4 JUILLETDÉCEMBRE 09Jun 01, 18 · The following are theexamples of hydrophilic grades of gelucire such as 50/13, 44/14, 48/16, 55/18, 35/10, 48/09 Among the above grades, gelucire 50/13 and 44/14 were selected for review as a lot of research works are published using these two grades 12 Gelucire ®
Gelucire 50/13 product page Gattefosse Published 10 Shohin et al, (Journal of Pharmaceutical Sciences Vol 103 pages Published February 14;Application Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Matrix for modified release, Multiparticulates;Functionality Solubilizer for poorlysoluble APIs and bioavailability enhancer Single excipient formulation system selfemulsifies in aqueous fluid
Provider of personal care ingredients and pharmaceutical excipients, Gattefossé has been exploring the very best of nature and science since 10Gelucire® 50/13 (stearoyl polyoxyl32 glycerides) is a nonionic waterdispersible surfactant for lipidbased formulations to solubilize and increase oral bioavailability of poorly watersoluble APIs Selfemulsifies in aqueous media forming a fine dispersion, ie, microemulsion (SMEDDS)Detailed Specifications for Labrafac™ PG from Gattefossé Product Specs;
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Application Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions;Other products like Gelucire® 50/13 and 48/16, due to their solidstate characteristics, are suitable for preparation of solid dispersions by melt extrusion or spray atomization for preparation of selfemulsifying solid dosage formsThe aim of this study was to develop a formulation containing fenofibrate and Gelucire(®) 50/13 (Gattefossé, France) in order to improve the oral bioavailability of the drug Particles from gas saturated solutions (PGSS) process was chosen for investigation as a
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Gelucire 50/13, and Gelucire 43/01 as lipid carriers Ranitidine HCl– lipid granules were prepared by the melt granulation technique and evaluated for in vitro floating and drug release The results revealed that the moderate amount of Gelucire 43/01 and ethyl celluloseGelucire® 44/14, Gelucire® 48/16, Gelucire® 50/13 and the Labrafil® series (Table 2) consist of selfemulsifying excipients that may be in SEDDS / SMEDDS Several of these products listed are liquid or semisolid, hence suitable for soft or hard shell capsules Other products, such as Gelucire® 48/16 and Gelucire® 50/13 areLabrafil® M 1944 CS;
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Functionality Oily phase for topical formulations Oily vehicle and solubilizer for solutionsThe aim of this study was to develop a formulation containing fenofibrate and Gelucire(®) 50/13 (Gattefossé, France) in order to improve the oral bioavailability of the drug Particles from gas saturated solutions (PGSS) process was chosen for investigation as a manufacturing process for producing a solid dispersionAbstract, page 267, page ) Elmalehm H el al, Probe into the physical properties of a Gelucire 44/14 pharmaceuitcal formulation Published online 14
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Gelucire® 44/14 Gelucire® 48/16 Gelucire® 50/13 Labrafac™ lipophile WL 1349 Labrafac™ PG Labrafil® M 1944 CS Labrafil® M 2125 CS Labrafil® M 2130 CS Labrasol® ALF Lauroglycol™ 90 Lauroglycol™ FCC Maisine® CCLabrasol®, Gelucire® 44/14, Gelucire® 48/16, Gelucire® 50/13 and the Labrafil® series (Table 2) consist of selfemulsifying excipients that may be in SEDDS / SMEDDS Several of these products listed are liquid or semisolid, hence suitable for soft or hard shell capsulesBetween gelucire 50/13 and poloxamer 1 and to formulate the optimized solid dispersion into immediate release tablets MATERIALS and METHODS Materials Bosentan was received as gift sample from MSN Pharma, India Gelucire 50/13 was received as gift sample from Gattefosse, India, Poloxamer 1 was procured from Sigma Aldrich, India
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Generic filters Hidden label Hidden labelGelucire 50/13 in a ratio of 1 to 175 (drug Gelucire) achieved a drug release of % in 4 hours, a 5fold increase compared to pure carvedilol When incorporating 10% Dαtocopheryl polyethylene glycol succinate (vitamin E TPGS/ TPGS) a higher drug release was observed (%) Parallel artificial membrane permeability assay was used toMar 01, 19 · Gelucire® 50/13 (Gattefossé) Lipids can affect biopharmaceutical properties of the drugs leading to improved drug solubility in the intestinal fluid, protection of the drug against enzymatic degradation as well as the formation of lipoproteins promoting the lymphatic transport of highly lipophilic drugs 10 , 21
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Thermal And Fractal Analysis Of Diclofenac Gelucire 50 13 Microparticles Obtained By Ultrasound Assisted Atomization Journal Of Pharmaceutical Sciences
USB2 US11/2,363 USA USB2 US B2 US B2 US B2 US A US A US A US B2 US B2 US B2 Authority US United States Prior art keywords composition isotretinoin skin disorder fatty acid acid esters Prior art date Legal status (The legal status is an assumptionGelucire 50/13 (HPMCHPCGel 50/13) were prepared by the same method stated above in the ratio of 111 In this case, the weighed samples of HPMC and HPC were dissolved in 2 ml of absolute ethanol while the Gelucire 50/13 was dissolved in 2 ml of methylene chloride 23 Preparation of the IndHPMCGel 50/13 and IndHPMCHPCGelGelucire® 50/13 A nonionic waterdispersible surfactant for lipidbased formulations to solubilize and increase oral bioavailability of poorly watersoluble APIs Selfemulsifies in aqueous media forming a fine dispersion, ie, microemulsion (SMEDDS)
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Gelucire® 50/13 A nonionic waterdispersible surfactant for lipidbased formulations to solubilize and increase oral bioavailability of poorly watersoluble APIs "Download ourJul 01, 09 · Gelucire 50/13 was provided by Gattefosse (Cedex, France) and has mp 50 °C and HLB 13 All other materials and reagents were of analytical grade of purity22 Methods221 Preparation of physical mixtureGelucire is a waxy pellet, so it is crushed to fine particles firstly to prepare the physical mixturePeceol™ Plurol® Oleique CC 497;
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Mar 18, 15 · The aim of this study was to develop a formulation containing fenofibrate and Gelucire(®) 50/13 (Gattefossé, France) in order to improve the oral bioavailability of the drug Particles from gas saturated solutions (PGSS) process was chosen for investigation as a manufacturing process for producing a solid dispersionGelucire® 50/13 Gattefossé Solubilizer for poorlysoluble APIs and bioavailability enhancer Single excipient formulation system selfemulsifies in aqueous fluid into coarse emulsion—LFCS Type III (SMEDDS) Modulation of drug release Lipid binder in melt processesMain components of Gelucire® 50/13 R=C16 or C18 Schematic structures PEG1500 esters O H R C O O 3 3 O C O R R C O O 3 3 Phospholipon® 90G Phospholipon® 90G was received as a gift sample from Phospholipid GmbH (Nattermannalle, Germany) This is a purified, deoiled, and granulated soy lecithin with a high phosphatidylcholine
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Gelucire 5013,CAS,,Gelucire 5013 suppliers Approved Bulk Manufacturers Want to be listed as an approved manufacturer (Free service but requires approvement)?An oral pharmaceutical composition of isotretinoin containing at least two lipidic excipients, one of them being hydrophilic (ie having an HLB value superiorGelucire® 50/13 Gattefossé Solubilizer for poorlysoluble APIs and bioavailability enhancer Single excipient formulation system selfemulsifies in aqueous fluid into coarse emulsion—LFCS Type III (SMEDDS) Modulation of drug release Lipid binder in melt processes
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An oral pharmaceutical composition of isotretinoin containing at least two lipidic excipients, one of them being hydrophilic (ie having an HLB value superiorLabrafil® M 2130 CS;WOA1 PCT/BE01/ BEW WOA1 WO A1 WO A1 WO A1 BE W BE W BE W WO A1 WO A1 WO A1 Authority WO WIPO (PCT) Prior art keywords isotretinoin pharmaceutical composition mixtures fatty acid formulation Prior art date
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Labrafac™ lipophile WL 1349;Dec 05, 07 · Gelucire® 44/14 has achieved official USPNF status with pending Food Additive (FCC) status Gelucire® 44/14 is a versatile semisolid lipidic excipient, proven to improve the bioavailability of poorly soluble drugs It has a high HLB (14) and can be used either alone or as part a self emulsifying formulation (SEDDS/SMEDDS)Gelucire® 44/14 A nonionic waterdispersible surfactant for lipidbased formulations to solubilize and increase oral bioavailability of poorly watersoluble APIs Selfemulsifies in aqueous media forming a fine dispersion, ie, microemulsion (SMEDDS)
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Jun , 12 · Application of Acconon C50 and Gelucire 50/13 as Both Solidifying and Emulsifying Agents for Medium Chain Triglycerides Journal of Excipients and Food Chemicals , Sl, v 3, n 2, p 92, june 12Labrafil® M 2125 CS;GELUCIRE 50/13 and GELUCIRE 53/10 can be used according to our invention, but GELUCIRE 50/13 has been found to be particularly effective It is composed of fatty acid (majority of C 16 and C 18) esters of glycerol, PEG esters and free PEG
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May 10, 18 · One excipient that has stimulated interest in lipidbased solid dispersion formulations is Gelucire 44/14 (Gattefosse Corp, St Priest, France) This selfemulsifying excipient that exists as a waxy semisolid at ambient room temperature is a mixture of glyceryl and PEG 1500 esters of longchain fatty acids and is listed in the European Pharmacopoeia asGelucire® 48/16, a novel carrier available in powder and pellet forms, is PEG32 stearate, while, conventional gelucires, Gelucire® 44/14 and Gelucire® 50/13 are lauroyl polyoxyl32glycerides NF and stearoyl polyoxyl32 glycerides NF respectively
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